Ovarian Cancer Canada

Western Regional Blog – BC, YK, AB, NWT and Nunavut

Update on the Management and the Role of Intraperitoneal Chemotherapy for Ovarian Cancer

“The most important prognostic factor for ovarian cancer survival is the ability to achieve optimal cytoreduction with no residual disease.”

Teo MC.

Curr Opin Obstet Gynecol. 2013 Nov 15. [Epub ahead of print]


Source: Centre for Peritoneal and Pelvic Disease Department of Surgical Oncology, National Cancer Centre (S) Department of General Surgery, Singapore General Hospital Department of Gynaecologic Oncology, KKWCH Duke-NUS Graduate Medical School Yong Loo Lin School of Medicine.


PURPOSE OF REVIEW: Ovarian cancer is the commonest gynaecological cancer and the fifth leading cause of cancer death in women worldwide. The majority of patients with ovarian cancer present at an advanced stage, and up to 70% of those treated with a curative approach eventually recur and succumb to their disease. This article examines the management of ovarian cancer over the years and the role of intraperitoneal chemotherapy in the treatment algorithm.

RECENT FINDINGS: The surgical paradigm for ovarian cancer has changed and the goal is optimal cytoreduction with no residual disease. Intraperitoneal chemotherapy has been found to be superior to intravenous treatment alone, and the combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has produced encouraging results with improved disease-free and overall survivals at acceptable morbidity and mortality rates.

SUMMARY: The most important prognostic factor for ovarian cancer survival is the ability to achieve optimal cytoreduction with no residual disease. CRS and HIPEC should be considered as an option for the management of advanced ovarian cancer and further trials are required to determine its role in both the primary and recurrent settings.

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