Ovarian Cancer Canada

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Endometriosis-associated ovarian cancers: Pathogenesis and consequences on daily practice

“Recent findings suggest an association between endometriosis and the entire type 1 ovarian tumors group including clear-cell, endometrioid and low-grade serous carcinomas. However, current evidence is lacking to draw definitive conclusion whether this association represents causality or the sharing of common risk factors.” 

[Article in French]

Borghese B, Santulli P, Vaiman D, Alexandre J, Goldwasser F, Chapron C.

J Gynecol Obstet Biol Reprod (Paris). 2013 Apr 8. pii: S0368-2315(13)00052-5. doi: 10.1016/j.jgyn.2013.02.013. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23578493?dopt=Abstract

Abstract 

Endometriosis is considered as a tumor-like lesion under the World Health Organization (WHO) classification of ovarian tumors. Data from large cohort and case-control studies indicate that patients with a history of endometriosis have an increased risk of ovarian cancer. Recent findings suggest an association between endometriosis and the entire type 1 ovarian tumors group including clear-cell, endometrioid and low-grade serous carcinomas. However, current evidence is lacking to draw definitive conclusion whether this association represents causality or the sharing of common risk factors. Nevertheless, assumption that endometriosis could be a precursor of malignancy raises many issues about serial screening, surgical management and surveillance of endometriosis. Beyond these concerns, endometriosis-associated ovarian cancers seem to be a genuine clinical entity as regards clinicopathological features. In view of the high incidence of endometriosis (10% of women of childbearing age), the low incidence of endometriosis-associated ovarian cancers and the psychological consequences for those women, systematic screening and surgical exploration seem very questionable in this context.

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This entry was posted on April 20, 2013 by in Research Updates and tagged , .

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